Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase
نویسندگان
چکیده
منابع مشابه
Global Analysis of Small Molecule Binding to Related Protein Targets
We report on the integration of pharmacological data and homology information for a large scale analysis of small molecule binding to related targets. Differences in small molecule binding have been assessed for curated pairs of human to rat orthologs and also for recently diverged human paralogs. Our analysis shows that in general, small molecule binding is conserved for pairs of human to rat ...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2016
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.6b06828